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Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma.
Luo P, Zhang Q, Shen S, An Y, Yuan L, Wong YK, Huang S, Huang S, Huang J, Cheng G, Tian J, Chen Y, Zhang X, Li W, He S, Wang J, Du Q. Luo P, et al. Asian J Pharm Sci. 2023 Nov;18(6):100874. doi: 10.1016/j.ajps.2023.100874. Epub 2023 Nov 30. Asian J Pharm Sci. 2023. PMID: 38149060 Free PMC article.
Hepatocellular carcinoma (HCC) is one of most common and deadliest malignancies. ...We demonstrated that Cel selectively targets the voltage-dependent anion channel 2 (VDAC2). Cel directly binds to the cysteine residues of VDAC2, and induces cytochrome …
Hepatocellular carcinoma (HCC) is one of most common and deadliest malignancies. ...We demonstrated that Cel selectively targe …
Ferroptosis and cuproptosis prognostic signature for prediction of prognosis, immunotherapy and drug sensitivity in hepatocellular carcinoma: development and validation based on TCGA and ICGC databases.
Ma Q, Hui Y, Huang BR, Yang BF, Li JX, Fan TT, Gao XC, Ma DY, Chen WF, Pei ZX. Ma Q, et al. Transl Cancer Res. 2023 Jan 30;12(1):46-64. doi: 10.21037/tcr-22-2203. Epub 2022 Dec 19. Transl Cancer Res. 2023. PMID: 36760376 Free PMC article.
BACKGROUND: Hepatocellular carcinoma (HCC) is a common malignancy. Ferroptosis and cuproptosis promote HCC spread and proliferation. ...RESULTS: TXNRD1 [hazard ratio (HR) =1.477, P<0.001], FTL (HR =1.373, P=0.001), GPX4 (HR =1.650, P=0.004), PRDX1 (HR =1.576, P=0 …
BACKGROUND: Hepatocellular carcinoma (HCC) is a common malignancy. Ferroptosis and cuproptosis promote HCC spread and prolifer …
Dysregulation and oncogenic activities of ubiquitin specific peptidase 2a in the pathogenesis of hepatocellular carcinoma.
Zhang X, Nadolny C, Chen Q, Ali W, Hashmi SF, Deng R. Zhang X, et al. Am J Cancer Res. 2023 Jun 15;13(6):2392-2409. eCollection 2023. Am J Cancer Res. 2023. PMID: 37424823 Free PMC article.
Currently, our understanding on USP2a dysregulation in subjects with hepatocellular carcinoma (HCC) and its roles in HCC pathogenesis is limited. ...Analysis of those USP2a target proteins revealed that USP2a's oncogenic activities are mediated through multiple path …
Currently, our understanding on USP2a dysregulation in subjects with hepatocellular carcinoma (HCC) and its roles in HCC patho …
The Effect of Ferroptosis-Related Genes on Prognosis and Tumor Mutational Burden in Hepatocellular Carcinoma.
Zhang H, Liu R, Sun L, Guo W, Hu X. Zhang H, et al. J Oncol. 2021 Aug 18;2021:7391560. doi: 10.1155/2021/7391560. eCollection 2021. J Oncol. 2021. PMID: 34457006 Free PMC article.
We analyzed the relationship between ferroptosis and tumor mutational burden in hepatocellular carcinoma (HCC). Eighty-four ferroptosis-related genes were analyzed by Cox regression and the least absolute shrinkage and selection operator method. Seven genes (SLC7A11 …
We analyzed the relationship between ferroptosis and tumor mutational burden in hepatocellular carcinoma (HCC). Eighty-four fe …
Construction of a prognostic risk model based on apoptosis-related genes to assess tumor immune microenvironment and predict prognosis in hepatocellular carcinoma.
Wang X, Ji C. Wang X, et al. BMC Gastroenterol. 2022 Aug 26;22(1):400. doi: 10.1186/s12876-022-02481-w. BMC Gastroenterol. 2022. PMID: 36028814 Free PMC article.
BACKGROUND: Hepatocellular carcinoma (HCC) is a serious malignant disease with high incidence, high mortality and poor prognosis. ...RESULTS: Nine genes (CDC25B, DAP3, ETF1, GSR, LGALS3, MGMT, PPP2R5B, SQSTM1 and VDAC2) were included in the prognostic risk mo …
BACKGROUND: Hepatocellular carcinoma (HCC) is a serious malignant disease with high incidence, high mortality and poor prognos …
Global analysis of HBV-mediated host proteome and ubiquitylome change in HepG2.2.15 human hepatoblastoma cell line.
Yuan S, Tanzeel Y, Tian X, Zheng D, Wajeeha N, Xu J, Ke Y, Zhang Z, Peng X, Lu L, Sun G, Guo D, Wang M. Yuan S, et al. Cell Biosci. 2021 Apr 17;11(1):75. doi: 10.1186/s13578-021-00588-3. Cell Biosci. 2021. PMID: 33865438 Free PMC article.
Hepatitis B virus (HBV) infection remains a major health issue worldwide and the leading cause of cirrhosis and hepatocellular carcinoma (HCC). It has been reported previously that HBV invasion can extensively alter transcriptome, the proteome of exosomes and host c …
Hepatitis B virus (HBV) infection remains a major health issue worldwide and the leading cause of cirrhosis and hepatocellular car …
Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin.
Maldonado EN, Sheldon KL, DeHart DN, Patnaik J, Manevich Y, Townsend DM, Bezrukov SM, Rostovtseva TK, Lemasters JJ. Maldonado EN, et al. J Biol Chem. 2013 Apr 26;288(17):11920-9. doi: 10.1074/jbc.M112.433847. Epub 2013 Mar 7. J Biol Chem. 2013. PMID: 23471966 Free PMC article.
Cells expressing predominantly VDAC3 were least sensitive to depolarization induced by increased free tubulin. In planar lipid bilayers, free tubulin inhibited VDAC1 and VDAC2 but not VDAC3. Erastin, a compound that interacts with VDAC, blocked and reversed mitochondrial d …
Cells expressing predominantly VDAC3 were least sensitive to depolarization induced by increased free tubulin. In planar lipid bilayers, fre …
Characterization of porin isoforms expressed in tumor cells.
Shinohara Y, Ishida T, Hino M, Yamazaki N, Baba Y, Terada H. Shinohara Y, et al. Eur J Biochem. 2000 Oct;267(19):6067-73. doi: 10.1046/j.1432-1327.2000.01687.x. Eur J Biochem. 2000. PMID: 10998068 Free article.
To explore possible differences in hexokinase binding sites of mitochondria between tumor cells and normal liver, we characterized porin isoforms expressed in tumor cells. Cloning experiments on the three porin isoforms, VDAC1, VDAC2 and VDAC3 from malignant tumor cell lin …
To explore possible differences in hexokinase binding sites of mitochondria between tumor cells and normal liver, we characterized porin iso …
Analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced proteome changes in 5L rat hepatoma cells reveals novel targets of dioxin action including the mitochondrial apoptosis regulator VDAC2.
Sarioglu H, Brandner S, Haberger M, Jacobsen C, Lichtmannegger J, Wormke M, Andrae U. Sarioglu H, et al. Mol Cell Proteomics. 2008 Feb;7(2):394-410. doi: 10.1074/mcp.M700258-MCP200. Epub 2007 Nov 12. Mol Cell Proteomics. 2008. PMID: 17998243 Free article.
A particularly intriguing finding was the up-regulation of the mitochondrial outer membrane pore protein, voltage-dependent anion channel-selective protein 2 (VDAC2), which was dependent on the presence of a functional aryl hydrocarbon receptor. The regulatability of VD …
A particularly intriguing finding was the up-regulation of the mitochondrial outer membrane pore protein, voltage-dependent anion channel-se …